:root{
  --indigo:#0B3A6B;--indigo2:#082E56;--green:#22C07A;--turq:#00A6B6;--coral:#FF6B6B;
  --grey:#CBD3E1;--ink:#0A3158;--text:#39546C;--soft:#F3FAFB;--soft2:#EAF7F7;--white:#fff;
  --line:#DCE8EE;--shadow:0 20px 55px rgba(11,58,107,.10);--radius:24px;--max:1200px;
}
*{box-sizing:border-box}
html{scroll-behavior:smooth}
body{margin:0;font-family:Montserrat,"Avenir Next",Avenir,Arial,sans-serif;color:var(--ink);line-height:1.6;background:#fff;-webkit-font-smoothing:antialiased}
a{color:inherit;text-decoration:none}
img{max-width:100%;display:block}
button{font:inherit}
.container{width:min(calc(100% - 40px),var(--max));margin:auto}
.eyebrow{font-size:.72rem;letter-spacing:.17em;font-weight:800;color:var(--turq);text-transform:uppercase;margin:0 0 14px}
h1,h2,h3,h4{line-height:1.06;letter-spacing:-.035em;margin-top:0}
h1{font-size:clamp(3.2rem,6vw,6.4rem);margin-bottom:25px}
h2{font-size:clamp(2.25rem,4vw,4rem);margin-bottom:20px}
h3{font-size:1.45rem;margin-bottom:12px}
p{margin:0 0 18px}
.muted{color:var(--text)}
.small{font-size:.8rem;color:var(--text)}
.btn{display:inline-flex;align-items:center;justify-content:center;gap:8px;min-height:50px;padding:0 22px;border-radius:9px;font-weight:800;font-size:.84rem;transition:.2s ease;border:0;cursor:pointer}
.btn:hover{transform:translateY(-2px)}
.btn.primary{background:var(--indigo);color:#fff;box-shadow:0 10px 24px rgba(11,58,107,.17)}
.btn.secondary{border:2px solid var(--indigo);background:#fff;color:var(--indigo)}
.btn.coral{background:var(--coral);color:#fff;box-shadow:0 10px 22px rgba(255,107,107,.20)}
.btn.white{background:#fff;color:var(--indigo)}
.btn.disabled{opacity:.6;pointer-events:none}
.tag{display:inline-flex;align-items:center;gap:7px;border-radius:999px;padding:7px 11px;background:#EAF8F6;color:#087A76;font-size:.7rem;font-weight:800}
.tag::before{content:"";width:7px;height:7px;background:var(--green);border-radius:50%}
.tag.plan::before{background:var(--coral)}
.tag.build::before{background:var(--turq)}

/* header */
.topline{background:var(--indigo);color:#fff;font-size:.68rem;text-transform:uppercase;letter-spacing:.17em;padding:7px 0}
header{position:sticky;top:0;z-index:100;background:rgba(255,255,255,.95);backdrop-filter:blur(14px);border-bottom:1px solid var(--line)}
.navrow{height:86px;display:flex;align-items:center;justify-content:space-between;gap:24px}
.brand{width:350px;max-width:40vw}
.brand img{width:100%;height:auto}
nav{display:flex;align-items:center;gap:23px;font-size:.78rem;font-weight:750}
nav a:hover{color:var(--turq)}
nav .nav-donate{background:var(--coral);color:#fff!important;padding:10px 16px;border-radius:999px}
.menu{display:none;border:0;background:none;width:44px}
.menu span{height:2px;background:var(--indigo);display:block;margin:6px}

/* hero */
.hero{position:relative;overflow:hidden;padding:90px 0 100px;background:
radial-gradient(circle at 10% 15%,rgba(0,166,182,.10),transparent 25%),
radial-gradient(circle at 88% 30%,rgba(34,192,122,.11),transparent 28%),
linear-gradient(180deg,#fff,#F5FBFB)}
.hero:after{content:"";position:absolute;left:-10%;right:-10%;bottom:-140px;height:245px;border-radius:50% 50% 0 0;background:linear-gradient(90deg,rgba(0,166,182,.08),rgba(34,192,122,.14));transform:rotate(-2deg)}
.hero-grid{position:relative;z-index:2;display:grid;grid-template-columns:1.05fr .95fr;gap:65px;align-items:center}
.hero h1 span{background:linear-gradient(90deg,var(--turq),var(--green));-webkit-background-clip:text;color:transparent}
.hero .lede{font-size:1.14rem;color:var(--text);max-width:690px}
.actions{display:flex;gap:12px;flex-wrap:wrap;margin-top:30px}
.hero-card{background:#fff;border:1px solid var(--line);border-radius:28px;box-shadow:var(--shadow);padding:32px}
.hero-card img{max-height:350px;width:100%;object-fit:contain}
.hero-card .caption{border-top:1px solid var(--line);padding-top:17px;margin-top:20px;font-size:.83rem;color:var(--text);font-weight:650}

/* four pillars */
.pillars{background:var(--indigo);color:#fff}
.pillar-grid{display:grid;grid-template-columns:repeat(4,1fr)}
.pillar-grid>div{padding:30px 24px;border-right:1px solid rgba(255,255,255,.14)}
.pillar-grid>div:last-child{border:0}
.pillar-grid span{font-size:.68rem;color:#69E7D5;font-weight:800}
.pillar-grid strong{display:block;font-size:1.03rem;margin:6px 0}
.pillar-grid p{font-size:.75rem;color:#D2E2EC;margin:0}

/* sections */
.section{padding:100px 0}
.soft{background:var(--soft)}
.split{display:grid;grid-template-columns:1fr 1fr;gap:75px;align-items:start}
.section-head{max-width:820px;margin-bottom:48px}
.section-head p{color:var(--text);font-size:1.02rem}
.cards{display:grid;gap:20px}
.cards.three{grid-template-columns:repeat(3,1fr)}
.cards.two{grid-template-columns:repeat(2,1fr)}
.card{background:#fff;border:1px solid var(--line);border-radius:20px;padding:30px;box-shadow:0 12px 35px rgba(11,58,107,.05)}
.card p{color:var(--text)}
.number{width:42px;height:42px;border-radius:50%;background:#E9F8F6;color:var(--turq);display:grid;place-items:center;font-size:.72rem;font-weight:800;margin-bottom:48px}
.card a{font-weight:800;color:var(--turq);font-size:.81rem}
.callout{background:linear-gradient(135deg,var(--indigo),#0D4E79);color:#fff;border-radius:25px;padding:36px}
.callout p{color:#D8E7EE}
.rule-link{display:inline-flex;gap:7px;color:var(--turq);font-weight:800}
.rule-link:hover span{transform:translateX(4px)}

/* research hub */
.hub-nav-wrap{background:#fff;border-top:1px solid var(--line);border-bottom:1px solid var(--line);position:sticky;top:119px;z-index:40}
.hub-nav{display:flex;gap:4px;overflow-x:auto;padding:10px 0;scrollbar-width:none}
.hub-nav a{white-space:nowrap;padding:9px 13px;border-radius:8px;font-size:.75rem;font-weight:750;color:var(--text)}
.hub-nav a:hover{background:var(--soft);color:var(--indigo)}
.hub-intro{display:grid;grid-template-columns:1.1fr .9fr;gap:60px;align-items:center}
.hub-stat-grid{display:grid;grid-template-columns:1fr 1fr;gap:13px}
.hub-stat{background:#fff;border:1px solid var(--line);border-radius:16px;padding:20px}
.hub-stat strong{font-size:1.55rem;display:block;color:var(--indigo)}
.hub-stat span{font-size:.72rem;color:var(--text)}
.workstream{position:relative;padding-top:40px}
.workstream>.wsno{position:absolute;top:0;left:30px;color:var(--turq);font-weight:850;font-size:.76rem;letter-spacing:.13em}
.workstream ul{padding-left:18px;color:var(--text)}
.workstream li{margin:8px 0}
.roadmap{display:grid;grid-template-columns:repeat(4,1fr);border-top:4px solid var(--turq)}
.roadmap>div{padding:26px 24px;border-right:1px solid var(--line)}
.roadmap>div:last-child{border:0}
.roadmap span{font-size:.68rem;font-weight:800;color:var(--turq);letter-spacing:.12em}
.roadmap h3{margin-top:17px}
.roadmap p{font-size:.82rem;color:var(--text)}
.project-table{border-top:1px solid var(--line)}
.project-row{display:grid;grid-template-columns:1.25fr .65fr .8fr .35fr;gap:18px;padding:19px 4px;border-bottom:1px solid var(--line);align-items:center}
.project-row.header{font-size:.68rem;letter-spacing:.12em;font-weight:800;text-transform:uppercase;color:var(--text)}
.project-row h4{font-size:.92rem;margin:0}
.project-row p{font-size:.75rem;color:var(--text);margin:3px 0 0}
.project-row .stage{font-size:.76rem;color:var(--text)}
.project-row .owner{font-size:.75rem;color:var(--text)}

/* evidence */
.evidence-grid{display:grid;grid-template-columns:.75fr 1.25fr;gap:60px}
.evidence-summary{position:sticky;top:180px;align-self:start}
.paper-list{border-top:1px solid var(--line)}
.paper{display:grid;grid-template-columns:70px 1fr auto;gap:18px;padding:22px 0;border-bottom:1px solid var(--line);align-items:start}
.paper .year{font-weight:800;color:var(--turq)}
.paper strong{font-size:.93rem}
.paper small{display:block;color:var(--text);margin-top:5px}
.paper a{font-size:.75rem;color:var(--turq);font-weight:800}

/* mechanism */
.mechanism{display:grid;grid-template-columns:repeat(7,auto);align-items:stretch;gap:10px;margin:35px 0}
.mech-box{padding:20px;border-radius:15px;background:#fff;border:1px solid var(--line);min-width:0}
.mech-box b,.mech-box span{display:block}
.mech-box b{font-size:.9rem}
.mech-box span{font-size:.7rem;color:var(--text);margin-top:6px}
.arrow{display:grid;place-items:center;color:var(--turq);font-weight:900}

/* therapies */
.therapy-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:18px}
.therapy{border-radius:18px;padding:26px;border:1px solid var(--line);background:#fff}
.therapy .status{font-size:.66rem;text-transform:uppercase;letter-spacing:.12em;font-weight:800;color:var(--turq)}
.therapy h3{margin-top:25px}
.therapy p{font-size:.86rem;color:var(--text)}
.warning{border-left:4px solid var(--coral);background:#FFF4F4;padding:18px 20px;color:var(--text);font-size:.86rem;margin-top:25px}

/* phenotype */
.pheno-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:16px}
.pheno{border:1px solid var(--line);border-radius:16px;padding:22px;background:#fff}
.pheno strong{display:block;margin-bottom:6px}
.pheno span{font-size:.78rem;color:var(--text)}

/* story */
.story{background:linear-gradient(135deg,var(--indigo2),#0B4771);color:#fff}
.story-grid{display:grid;grid-template-columns:.55fr 1.45fr;gap:75px;align-items:center}
.story-icon img{max-width:350px}
.story p{color:#D6E5ED;max-width:760px}

/* collab */
.collab-grid{display:grid;grid-template-columns:1fr 1fr;gap:55px}
.collab-list{background:#fff;border:1px solid var(--line);border-radius:20px;padding:28px}
.collab-list ul{list-style:none;padding:0;margin:18px 0 0}
.collab-list li{padding:11px 0 11px 28px;border-bottom:1px solid #EDF2F5;position:relative}
.collab-list li::before{content:"";position:absolute;left:0;top:18px;width:10px;height:6px;border-left:2px solid var(--green);border-bottom:2px solid var(--green);transform:rotate(-45deg)}

/* get involved */
.involve-grid{display:grid;grid-template-columns:repeat(4,1fr);gap:15px}
.involve{padding:26px;border-radius:18px;border:1px solid var(--line);background:#fff}
.involve .ico{font-size:1.6rem;margin-bottom:28px}
.involve p{font-size:.82rem;color:var(--text)}

/* faq */
.faq{max-width:900px}
details{border-bottom:1px solid var(--line);padding:18px 0}
summary{font-weight:800;cursor:pointer;list-style:none}
summary::-webkit-details-marker{display:none}
details p{color:var(--text);padding-right:30px;margin-top:12px}

/* cta/footer */
.cta{padding:72px 0;background:linear-gradient(90deg,var(--turq),#119D91);color:#fff}
.cta-grid{display:grid;grid-template-columns:1.4fr .6fr;gap:50px;align-items:center}
.cta p{color:#E4FFFF}
footer{background:#062847;color:#fff;padding:58px 0 24px}
.footer-grid{display:grid;grid-template-columns:1.25fr .75fr 1fr;gap:50px}
.footer-logo{width:330px;filter:brightness(0) invert(1);opacity:.97}
footer p,footer a{color:#BCD2DF;font-size:.79rem}
footer strong{font-size:.82rem}
.footer-links{display:flex;flex-direction:column;gap:8px}
.footer-bottom{border-top:1px solid rgba(255,255,255,.12);margin-top:38px;padding-top:18px;font-size:.7rem;color:#8FAABA}

/* responsive */
@media(max-width:980px){
 nav{display:none;position:absolute;top:119px;left:0;right:0;background:#fff;padding:20px;flex-direction:column;align-items:stretch;border-bottom:1px solid var(--line)}
 nav.open{display:flex}
 .menu{display:block}
 .hero-grid,.split,.hub-intro,.evidence-grid,.story-grid,.collab-grid,.cta-grid{grid-template-columns:1fr}
 .pillar-grid,.roadmap,.involve-grid{grid-template-columns:1fr 1fr}
 .cards.three,.therapy-grid,.pheno-grid{grid-template-columns:1fr 1fr}
 .project-row{grid-template-columns:1fr 1fr}
 .project-row.header{display:none}
 .evidence-summary{position:static}
 .mechanism{grid-template-columns:1fr}
 .arrow{transform:rotate(90deg)}
 .hub-nav-wrap{top:119px}
 .footer-grid{grid-template-columns:1fr 1fr}
}
@media(max-width:650px){
 .container{width:min(calc(100% - 28px),var(--max))}
 .topline{display:none}
 .navrow{height:76px}
 nav{top:76px}
 .brand{max-width:72vw}
 .hero,.section{padding:72px 0}
 h1{font-size:3.2rem}
 .pillar-grid,.cards.three,.cards.two,.roadmap,.therapy-grid,.pheno-grid,.involve-grid,.footer-grid{grid-template-columns:1fr}
 .pillar-grid>div{border-right:0;border-bottom:1px solid rgba(255,255,255,.14)}
 .hub-nav-wrap{top:76px}
 .project-row{grid-template-columns:1fr}
 .paper{grid-template-columns:55px 1fr}
 .paper a{grid-column:2}
 .story-icon img{max-width:210px}
}

.page-hero{padding:82px 0;background:linear-gradient(135deg,#F8FCFD,#EAF8F7);border-bottom:1px solid var(--line)}
.page-grid{display:grid;grid-template-columns:1.3fr .7fr;gap:60px;align-items:center}
.page-icon{max-width:300px;justify-self:end}
.longcopy{max-width:900px}.longcopy h2{margin-top:58px;font-size:2.15rem}.longcopy h2:first-child{margin-top:0}.longcopy p{color:var(--text)}
.home-teaser{background:#fff;border:1px solid var(--line);border-radius:20px;padding:29px;box-shadow:0 12px 35px rgba(11,58,107,.05)}
.home-teaser h3{margin-top:36px}.home-teaser p{color:var(--text)}.home-teaser a{color:var(--turq);font-weight:800;font-size:.82rem}
.atlas-toolbar{position:sticky;top:119px;z-index:50;background:rgba(255,255,255,.97);backdrop-filter:blur(10px);border-bottom:1px solid var(--line);padding:14px 0}
.search-row{display:grid;grid-template-columns:1.5fr .55fr .65fr auto;gap:10px}
.search-row input,.search-row select{width:100%;border:1px solid #C9DAE3;border-radius:10px;padding:12px 13px;font:inherit;color:var(--ink);background:#fff}
.search-row button{border:0;border-radius:10px;background:var(--indigo);color:#fff;font-weight:800;padding:0 18px}
.atlas-meta{display:flex;justify-content:space-between;gap:20px;align-items:center;margin:24px 0}.atlas-meta p{margin:0;color:var(--text);font-size:.82rem}
.atlas-grid{display:grid;grid-template-columns:repeat(2,1fr);gap:18px}
.evidence-card{border:1px solid var(--line);border-radius:19px;padding:25px;background:#fff;box-shadow:0 10px 25px rgba(11,58,107,.04)}
.evidence-card .top{display:flex;justify-content:space-between;gap:15px;align-items:flex-start}.evidence-card .year{color:var(--turq);font-weight:850;font-size:.8rem}
.evidence-card h3{font-size:1.22rem;margin:16px 0 8px}.evidence-card .journal{font-size:.75rem;color:var(--text);font-weight:700}
.evidence-card .summary{font-size:.84rem;color:var(--text);margin-top:16px}.chips{display:flex;gap:6px;flex-wrap:wrap;margin:14px 0}
.chip{background:#EDF8F7;color:#087B76;border-radius:999px;padding:5px 8px;font-size:.63rem;font-weight:760}.chip.alt{background:#EEF3F9;color:#365A7B}
.evidence-card details{border-top:1px solid var(--line);margin-top:17px;padding-top:14px}.evidence-card summary{cursor:pointer;font-weight:800;font-size:.76rem}
.detail-grid{display:grid;grid-template-columns:1fr 1fr;gap:12px;margin-top:13px}.detail-grid div{font-size:.72rem;color:var(--text)}.detail-grid b{display:block;color:var(--ink);margin-bottom:3px}
.pubmed{display:inline-flex;margin-top:14px;color:var(--turq);font-weight:800;font-size:.76rem}.atlas-empty{grid-column:1/-1;padding:50px;text-align:center;background:var(--soft);border-radius:18px;color:var(--text)}
.atlas-note{margin-top:30px;background:#F8FBFC;border:1px solid var(--line);padding:22px;border-radius:15px;font-size:.82rem;color:var(--text)}
@media(max-width:980px){.page-grid{grid-template-columns:1fr}.page-icon{justify-self:start;max-width:220px}.search-row{grid-template-columns:1fr 1fr}.atlas-toolbar{top:119px}}
@media(max-width:650px){.page-hero{padding:68px 0}.atlas-grid{grid-template-columns:1fr}.search-row{grid-template-columns:1fr}.atlas-toolbar{top:76px}.atlas-meta{align-items:flex-start;flex-direction:column}.detail-grid{grid-template-columns:1fr}}

/* Featured fundraising campaign */
.fundraiser-feature{background:#fff}.fundraiser-grid,.campaign-detail{display:grid;grid-template-columns:.82fr 1.18fr;gap:64px;align-items:center}.fundraiser-poster,.campaign-poster{border-radius:24px;overflow:hidden;box-shadow:0 24px 60px rgba(11,58,107,.14);background:#fff}.fundraiser-poster img,.campaign-poster img{width:100%;height:auto}.lede-small,.campaign-lede{font-size:1.05rem;color:var(--text)}.event-facts{display:grid;grid-template-columns:repeat(3,1fr);gap:12px;margin:28px 0}.event-facts div,.campaign-facts div{border:1px solid var(--line);background:var(--soft);border-radius:14px;padding:16px}.event-facts strong,.event-facts span,.campaign-facts span,.campaign-facts strong,.campaign-facts small{display:block}.event-facts strong,.campaign-facts span{font-size:.66rem;letter-spacing:.10em;text-transform:uppercase;color:var(--turq);margin-bottom:5px}.event-facts span,.campaign-facts strong{font-size:.82rem;color:var(--ink)}.campaign-facts{display:grid;grid-template-columns:repeat(3,1fr);gap:12px;margin:28px 0}.campaign-facts small{font-size:.72rem;color:var(--text);margin-top:5px}.campaign-copy p:not(.eyebrow){color:var(--text)}.notice{border-left:4px solid var(--coral);background:#FFF5F5;padding:18px 20px;border-radius:0 12px 12px 0;color:var(--text);font-size:.84rem;margin:24px 0}.rule-link{display:inline-flex;gap:7px;color:var(--turq);font-weight:800;font-size:.81rem}.rule-link span{transition:.2s}.rule-link:hover span{transform:translateX(4px)}
@media(max-width:900px){.fundraiser-grid,.campaign-detail{grid-template-columns:1fr}.fundraiser-poster,.campaign-poster{max-width:560px}.event-facts,.campaign-facts{grid-template-columns:1fr 1fr}}
@media(max-width:620px){.event-facts,.campaign-facts{grid-template-columns:1fr}.fundraiser-grid,.campaign-detail{gap:36px}}


/* Campaigns and fundraiser cards */
.campaign-card-grid{display:grid;grid-template-columns:repeat(4,1fr);gap:20px}
.campaign-tile{background:#fff;border:1px solid var(--line);border-radius:20px;overflow:hidden;box-shadow:0 14px 35px rgba(11,58,107,.06)}
.campaign-image{display:block;background:#edf7f7;aspect-ratio:4/5;overflow:hidden}
.campaign-image img{width:100%;height:100%;object-fit:cover;transition:transform .3s ease}
.campaign-tile:hover .campaign-image img{transform:scale(1.018)}
.campaign-tile-copy{padding:24px}
.campaign-tile-copy h3{font-size:1.42rem;margin:10px 0}
.campaign-tile-copy p{font-size:.84rem;color:var(--text)}
.campaign-label{display:inline-flex;border-radius:999px;padding:6px 9px;font-size:.63rem;font-weight:800;text-transform:uppercase;letter-spacing:.08em;background:#eaf8f6;color:#087b76}
.campaign-label.coming{background:#eef3f9;color:#385c7c}
.coming-soon{display:block;color:var(--indigo);font-size:.78rem;margin-top:14px}
.campaigns-more{text-align:center;margin-top:34px}
.campaign-overview-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:18px}
@media(max-width:1050px){.campaign-card-grid{grid-template-columns:1fr 1fr}.campaign-overview-grid{grid-template-columns:1fr 1fr}}
@media(max-width:650px){.campaign-card-grid,.campaign-overview-grid{grid-template-columns:1fr}}

/* Public launch polish */
.story-actions{display:flex;gap:12px;flex-wrap:wrap;margin-top:28px}.privacy-note{font-size:.75rem;color:var(--text);margin-top:14px;max-width:620px}.family-connect .btn{margin-top:8px}
@media(max-width:1100px){.campaign-card-grid{grid-template-columns:1fr 1fr}}
@media(max-width:650px){.campaign-card-grid,.campaign-overview-grid{grid-template-columns:1fr}.story-actions{flex-direction:column;align-items:flex-start}}

.story-photo{margin:28px 0 36px}.story-photo img{width:100%;max-width:760px;border-radius:22px;box-shadow:0 18px 48px rgba(11,58,107,.14)}.story-photo figcaption{font-size:.76rem;color:var(--text);margin-top:10px}